Impact of Macitentan on the Health-Related Quality of Life in Pulmonary Arterial Hypertension

IFIA Scientific Articles

Abstract

Background: Pulmonary arterial hypertension is a progressive disease of the lung vascular system which causes patients functional limitations and reduces their Health-Related Quality of Life (HRQoL). This study was aimed at determining the effectiveness of Macitentan on the HRQoL of Iranian PAH patients with an emphasis on 10 questionnaires.
Methods: 31 idiopathic class I pulmonary hypertension patients were enrolled in this cohort study. Patients completed the emphasis 10 questionnaire at baseline and 6 months after Macitentan consumption. The absolute changes in emphasis 10 scores were calculated. The effect of Macitentan on functional activity and paraclinical indexes was assessed.

Conclusion: Treatment with Macitentan significantly improved patient functional activity and reduced the mean hospitalization days. Thus, due to the low side effects and high efficacy, it can be advised as the first line of treatment.
Keywords: Emphasis, Macitentan, Pulmonary hypertension, Quality of life HRQoL of Iranian PAH patients by the emphasis 10 questionnaires.